suPARnostic® TurbiLatex for rapid and high volume suPAR detection
About suPARnostic® TurbiLatex
The suPARnostic® TurbiLatex is a CE-IVD approved particle-enhanced turbidimetric immunoassay (PETIA) for quantitative measurement of suPAR in human plasma (K2-EDTA or lithium heparin).
Validated on leading automated chemistry platforms, including Roche Cobas, Siemens Atellica, Abbott Architect/Alinity, and Beckman Coulter systems, it delivers fast and reliable results to support clinical decision making.
suPAR is the soluble form of uPAR (urokinase plasminogen activator receptor), a strong biomarker of immune activation and inflammation that elevates with disease presence and severity.
Read more about suPAR here.
Important clinical benefits of suPAR:
- Aid in prioritization of patients who can be discharged after treatment
- Assistance in the identification of high-risk patients with unaffected vital signs
- Shortens the average patient-length-of-stay and reduces the cost of healthcare
How the suPARnostic® TurbiLatex Works
The suPARnostic® TurbiLatex is a particle-enhanced turbidimetric immunoassay that measures suPAR levels in plasma (K2-EDTA or lithium heparin). The test uses latex particles coated with antibodies that bind specifically to suPAR. Binding of suPAR to these antibody-coated latex particles leads to agglutinated, aggregated immune complexes, which increases turbidity (scattering of light). This turbidity is measured photometrically on automated clinical chemistry analysers (e.g. Roche Cobas, Siemens Atellica, Abbott Architect, etc.).
Why choose suPARnostic® TurbiLatex?
- Fast & automated: The assay delivers results in about 10 minutes on routine clinical chemistry analysers.
- Validated & CE-IVD approved: suPARnostic® TurbiLatex is a quantitative, CE-marked in vitro diagnostic test, validated on multiple major platforms including Roche cobas®, Abbott Architect, Siemens, and Beckman Coulter systems.
- Supports clinical decisions: By quantifying suPAR levels, the test aids in risk stratification, triage decisions, and prognosis in some cases for patients in the Emergency Department (ED) and Intensive Care Unit (ICU). suPAR is a strong biomarker of inflammation, immune activation, and disease progression.
- Reliable performance: Delivers precise and consistent results across the validated measuring range (1.8–16.0 ng/mL) with demonstrated linearity up to 26.5 ng/mL. The assay shows no prozone effect at clinically relevant concentrations, ensuring accuracy even in high suPAR samples.
- Integrated quality control: Routine use of calibrators (#T020) and controls (#T030) ensures accuracy and reproducibility of results, with calibration recommended at least monthly and after each new reagent lot.
- Improves patient management: Clinical studies show that high suPAR (6. ng/mL) identifies patients at higher risk of adverse outcomes, enabling targeted resource allocation with their respective health economic impacts.
Product Details
The suPARnostic® TurbiLatex test is a latex particle-enhanced turbidimetric immunoassay that quantitatively determines the suPAR level in human K2-EDTA- or Lithium Heparin plasma samples.
The suPARnostic® TurbiLatex product is validated for the Roche Diagnostics Cobas c111, c303, c501/2, c701/2, Pure and Pro systems, the Siemens Atellica, and ADVIA Chemistry XPT, the Abbott Architect c, and Alinity ci systems and Beckman Coulter 5800.
Format: Ready-to-use two-reagent kit (Reagent 1: Dilution buffer; Reagent 2: Latex particle reagent)
Assay Time: 10 minutes
Sample Type: Human K2-EDTA plasma; Human Lithium-Heparin plasma
Measuring Range: 1.8–16.0 ng/mL
Reagent Shelf Life: 2 years
Product contains
- Reagent 1: Dilution Buffer
- Reagent 2: Latex Particles coated with anti-suPAR antibodies
Product Code
Product no. T001 : suPARnostic® TurbiLatex Reagents
Documentation
Product Details
Quality control of the suPARnostic® TurbiLatex Reagents should be performed with the suPARnostic® TurbiLatex Controls.
Quality control should be performed according to the laboratory guidelines. Ranges and limits should be fitted to the specific laboratory’s experience and knowledge.
Format: 3 Ready-to-use controls (1 mL each)
Calibrator Shelf Life: 12 months;
Product contains
- 1 mL of each Control 1-3 (Low, Medium, High suPAR level)
- Certificate of analysis with concentrations is provided with each kit
Product Code
Product no. T030: suPARnostic® TurbiLatex Controls
Documentation
Product Details
Together with the suPARnostic® TurbiLatex Reagents, the suPARnostic® TurbiLatex Calibrators should be used for calibration.
It is recommended to repeat the calibration at least once a month. In addition, it is required to recalibrate when a new batch of the suPARnostic® TurbiLatex Reagents is used.
The suPARnostic® Calibrators are used to establish a calibration curve which is used to interpolate the suPAR measurements.
Format: six ready-to-use liquid calibrators, 1 mL each
Calibrator Shelf Life: 12 months
The product contains
- 1 mL of each Calibrator
Product Code
Product no. T020: suPARnostic® TurbiLatex Calibrators
